NALP12 (NLRP12) Rabbit Polyclonal Antibody

CAT#: AP18136PU-N

NALP12 (NLRP12) rabbit polyclonal antibody

Product Images

(LEFT) Western blot analysis of NLRP12 Antibody in HL-60 cell line lysates (35ug/lane). NLRP12 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of NLRP12 Antibody in mouse testis tissue lysates (35ug/lane). NLRP12 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human NLRP12
• Specificity: This antibody reacts to NALP2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chrmatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens NLR family, pyrin domain containing 12 (NLRP12), transcript variant 1
• Database Link:
  Entrez Gene 378425 MouseEntrez Gene 91662 Human
• Background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes.
• Synonyms: NLRP12, PYPAF7, RNO