Rb (RB1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP18176PU-N

Rb (RB1) (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of RB1 Antibody (C-term) in 293 cell line lysates (35ug/lane). RB1 (arrow) was detected using the purified Pab. (2ug/ml)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the C-terminal region of human RB1
• Specificity: This antibody reacts to RB1.
• Formulation: PBS with 0.09% (W/V) sodium az
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens RB transcriptional corepressor 1 (RB1)
• Database Link:
  Entrez Gene 5925 Human
• Background: RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. This protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1.
• Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer