TAOK1 (C-term) Rabbit Polyclonal Antibody

CAT#: AP20077PU-N

TAOK1 (C-term) rabbit polyclonal antibody, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution ELISA.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Reactivities Bat, Bovine, Canine, Chicken, Equine, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Xenopus
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen TAOK1 antibody was raised against synthetic 17 amino acid peptide from C-Terminus of human TAOK1.
Specificity Reacts with C-Terminus TAO Kinase 1 (TAOK1).
Formulation PBS containing 0.09% Sodium Azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration 1 mg/ml
Purification Immunoaffinity Chromatography
Gene Name Homo sapiens TAO kinase 1 (TAOK1), transcript variant 1
Background TAOK1 is an upstream activator of Mark. TAOK1 phosphorylated Mark on a threonine within its activation loop. In brain, TAOK1 also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, TAOK1 activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. TAOK1 also activated JNK in vitro. Overexpression of TAOK1 in a human nonsmall cell lung carcinoma cell line induced apoptotic morphologic changes, including cell contraction, membrane blebbing, and apoptotic body formation. Apoptotic stimuli increased the catalytic activity of endogenous TAOK1 and JNK, and dominant-negative JNK or JNK inhibition blocked the apoptotic morphologic responses to TAOK1. TAOK1 also stimulated cleavage and activation of ROCK1 by caspases, leading to cell contraction and membrane blebbing. TAOK1 was itself a substrate for caspase-3. TAOK1 is indeed involved in the execution phase of apoptosis.
Synonyms Serine/threonine-protein kinase TAO1, KFC-B, MAP3K16, KIAA1361
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways MAPK signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.