DAP Kinase 2 (DAPK2) Rabbit Polyclonal Antibody

CAT#: AP20220PU-N

DAP Kinase 2 (DAPK2) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry analyzes of DAPK2 antibody (AP20220PU-N) in paraffin-embedded human skeletal muscle tissue.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of DAPK2 protein.
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen, purity is > 95% (by SDS-PAGE)
• Gene Name: Homo sapiens death associated protein kinase 2 (DAPK2)
• Database Link:
  Entrez Gene 13143 MouseEntrez Gene 300799 RatEntrez Gene 23604 Human
• Background: DAP (death associated protein) kinase and ZIP kinase are members of a novel protein kinase family, the members of which have the capacity to mediate apoptosis through their catalytic activities. DAP kinase contains a “death domain” and has been shown to mediate gamma interferon-induced apoptosis. The introduction of DAP kinase into highly metastatic carcinoma clones lacking DAP kinase expression was shown to result in the suppression of metastasis, thus linking suppression of apoptosis to metastasis. ZIP kinase contains a leucine zipper domain, which is necessary for homodimerization and for interaction with other leucine zipper proteins. ZIP kinase dimerizes with ATF-4, an ATF/CREB transcription factor family member that contains a leucine zipper. Overexpression of ZIP kinase was shown to result in morphological changes associated with apoptosis in NIH/3T3 cells.
• Synonyms: DAP kinase 2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Bladder cancer, Pathways in cancer