HDAC3 Rabbit Polyclonal Antibody

CAT#: AP20235PU-N

HDAC3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of SMAP45 antibody (Cat.-No.: AP20235PU-N) in extracts from PC12 cells.

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  Immunohistochemistry analyzes of SMAP45 antibody (AP20235PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
  Immunoflourescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of SMAP45 protein.
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 50 kDa
• Gene Name: Homo sapiens histone deacetylase 3 (HDAC3)
• Database Link:
  Entrez Gene 15183 MouseEntrez Gene 84578 RatEntrez Gene 8841 Human
  UniProt ID O15379
• Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone acetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
• Synonyms: Histone deacetylase 3, RPD3-2, SMAP45, HD3

Reference Data

• Protein Families: Druggable Genome, Transcription Factors