CD19 Rabbit Polyclonal Antibody

CAT#: AP20344PU-N

CD19 rabbit polyclonal antibody, Aff - Purified


USD 370.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution Western blot: 1/500-1/1000.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 490-540 of Human CD19.
Specificity This antibody detects endogenous levels of CD19 protein.
Formulation PBS, pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 61 kDa
Gene Name Homo sapiens CD19 molecule (CD19), transcript variant 2
Background CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin- like domains. CD19 is selectively expressed on the cell surface of B lymphocytes, where it activates intracellular signaling cascades involving both Ras and phosphatidylinositol 3-kinase pathways. Activation of CD19 results in cross-linking of the membrane protein immunoglobulin chains and the subsequent association with Src family protein tyrosine kinases (PTK). Expression of CD19 is continuous throughout B cell development and through terminal differentiation of B cells into plasma cells. CD19 forms functional complexes with B lymphocyte surface proteins, including integrin β1, CD21 and CD81, which are involved in regulating B cell development.
Synonyms Leu-12, B-cell marker
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Hematopoietic cell lineage, Primary immunodeficiency

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.