ADCY5 (+ADCY6) Rabbit Polyclonal Antibody

CAT#: AP20397PU-N

ADCY5 (+ADCY6) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of ADCY 5/6 antibody at 1/500 dilution Lane 1:Hela cell lysate Lane 2:Raw264.7 cell lysate Lane 3:PC12 cell lysate Lane 4:Rat brain tissue lysate

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  Immunohistochemistry analysis of A Cyclase V/VI Antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 1111-1160 of Human ADCY 5.
• Specificity: This antibody detects endogenous levels of A Cyclase V/VI protein.
  (region surrounding Phe1052)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 138 kDa
• Gene Name: Homo sapiens adenylate cyclase 5 (ADCY5), transcript variant 1
• Database Link:
  Entrez Gene 64532 RatEntrez Gene 224129 MouseEntrez Gene 111 Human
• Background: A cyclase V, also known as ADCY5, is a 1,261 amino acid Adenylyl cyclase that localizes to cellular membranes and contains two guanylate cyclase domains. Similar to other A cyclase proteins, A cyclase V uses magnesium as a cofactor to catalyze the conversion of ATP to cAMP. A cyclase VI, also known as ADCY6 (adenylate cyclase type 6), is a 1,168 amino acid A cyclase that localizes to the membrane and contains two guanylate cyclase domains. Using magnesium as a cofactor, A cyclase VI functions as a calcium-inhibitable A cyclase that catalyzes the conversion of ATP to 3',5'-cyclic AMP and diphosphate and plays a role in a variety of events throughout the body. Multiple isoforms of A cyclase VI exist due to alternative splicing events.
• Synonyms: ADCY5, Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Melanogenesis, Oocyte meiosis, Progesterone-mediated oocyte maturation, Purine metabolism, Vascular smooth muscle contraction