TPTEP2-CSNK1E Rabbit Polyclonal Antibody

CAT#: AP20419PU-N

TPTEP2-CSNK1E rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Casein Kinase Ie antibody in extracts from LOVO cells.

• 

  Immunohistochemistry analyzes of Casein Kinase I?µ antibody in paraffin-embedded human placenta tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 250-350 of Human Casein Kinase Iε.
• Specificity: This antibody detects endogenous levels of Casein Kinase Iε protein.
  (region surrounding Pro301)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 47 kDa
• Gene Name: Homo sapiens casein kinase 1 epsilon (CSNK1E), transcript variant 2
• Database Link:
  Entrez Gene 27373 MouseEntrez Gene 102800317 Human
  UniProt ID P49674
• Background: Casein kinase I (also designated CKI) and casein kinase II (also designated CKII) compose a family of serine/ threonine protein kinases which are present in all eukaryotes examined to date. CKI family members, which include CKIα, γ, ε and δ, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an α2β2 or an αα'β2 structure. The α catalytic subunit is stimulated by the β regulatory subunit, which undergoes autophosphorylation. CKII activity is high in the cytosol and nucleus of proliferating and differentiating cells. CKII is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.
• Synonyms: CKI-epsilon, CKIe, CSNK1E

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Circadian rhythm - mammal, Hedgehog signaling pathway, Wnt signaling pathway