Dystrophia myotonica protein kinase (DMPK) Rabbit Polyclonal Antibody

CAT#: AP20433PU-N

Dystrophia myotonica protein kinase (DMPK) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of DMPK antibody (Cat.-No.: AP20433PU-N) in extracts from Jurkat cell.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of DMPK protein.
  (region surrounding Arg30)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 70 kDa
• Gene Name: Homo sapiens dystrophia myotonica protein kinase (DMPK), transcript variant 3
• Database Link:
  Entrez Gene 1760 Human
  UniProt ID Q09013
• Background: Myotonic dystrophy protein kinase (DMPK) is a ulti-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis. DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction. DM arises through expansion of CTG repeats in the 3' UTR of the DMPK gene. Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus. These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype. Other substrates for DMPK include myogenin, Ltype calcium channels, and Phospholemman (PLM).
• Synonyms: Myotonin-protein kinase, DM-kinase, MT-PK, MDPK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase