ELAVL2 Rabbit Polyclonal Antibody

CAT#: AP20434PU-N

ELAVL2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Hel-N1 antibody (Cat.-No.: AP20434PU-N) in extracts from HepG2 cell.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Hel-N1 protein.
  (region surrounding Ser27)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 38 kDa
• Gene Name: Homo sapiens ELAV like neuron-specific RNA binding protein 2 (ELAVL2), transcript variant 1
• Database Link:
  Entrez Gene 15569 MouseEntrez Gene 286973 RatEntrez Gene 1993 Human
• Background: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.
• Synonyms: ELAV-like protein 2, Hu-antigen B, Hel-N1

Reference Data

• Protein Families: Transcription Factors