FOXC1 (+FOXC2) Rabbit Polyclonal Antibody

CAT#: AP20435PU-N

FOXC1 (+FOXC2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of FoxC1/2 antibody (Cat.-No.: AP20435PU-N) in extracts from RAW264.7.

• 

  Immunohistochemistry analyzes of FoxC1/2 antibody (Cat.-No.: AP20435PU-N) in paraffin-embedded human prostate carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human FoxC1.
• Specificity: This antibody detects endogenous levels of FoxC1/2 protein.
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~57 kDa
• Gene Name: Homo sapiens forkhead box C1 (FOXC1)
• Database Link:
  Entrez Gene 17300 MouseEntrez Gene 364706 RatEntrez Gene 2296 Human
  UniProt ID Q12948
• Background: FOXC2 is a member of forkhead/winged helix transcription factor family whose members serve as key regulators in embryogenesis and cell differentiation. FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the β-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition. Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity. FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro. FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs and double rows of eyelashes (distichiasis). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development.
• Synonyms: Forkhead box protein C1, FREAC-3

Reference Data

• Protein Families: Druggable Genome, Transcription Factors