Constitutive androstane receptor (NR1I3) Rabbit Polyclonal Antibody

CAT#: AP20444PU-N

Constitutive androstane receptor (NR1I3) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MB67 antibody (Cat.-No.: AP20444PU-N) in extracts from Jurkat cells.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of MB67 protein.
  (region surrounding Thr102)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 35 kDa
• Gene Name: Homo sapiens nuclear receptor subfamily 1 group I member 3 (NR1I3), transcript variant 2
• Database Link:
  Entrez Gene 9970 Human
• Background: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CAR, MB67

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors