KIAA1967 (CCAR2) Rabbit Polyclonal Antibody

CAT#: AP20449PU-N

KIAA1967 (CCAR2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of KIAA1967 / DBC-1 in A549 whole cell lysate using KIAA1967 antibody (Cat.-No. AP20449PU-N).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of KIAA1967 / DBC-1 protein.
  (region surrounding Gln455)
• Formulation: Phosphate buffered saline (PBS) with 15mM Sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95%; by SDS-PAGE)
• Predicted Protein Size: ~ 102.0 kDa
• Gene Name: Homo sapiens cell cycle and apoptosis regulator 2 (CCAR2), transcript variant 1
• Database Link:
  Entrez Gene 57805 Human
• Background: KIAA1967 / DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth.
• Synonyms: KIAA1967, DBC1, Deleted in breast cancer gene 1 protein, DBC.1, DBC-1, p30 DBC