KIAA1967 (CCAR2) Rabbit Polyclonal Antibody
Other products for "CCAR2"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1/500-1/1000. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of KIAA1967 / DBC-1 protein. (region surrounding Gln455) |
Formulation | Phosphate buffered saline (PBS) with 15mM Sodium azide, approx. pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography (> 95%; by SDS-PAGE) |
Predicted Protein Size | ~ 102.0 kDa |
Gene Name | Homo sapiens cell cycle and apoptosis regulator 2 (CCAR2), transcript variant 1 |
Database Link | |
Background | KIAA1967 / DBC-1 (deleted in breast cancer gene 1 protein), also known as p30 DBC protein, is one of the genes located within the region of chromosome 8 (8p21-8p23) that is homozygously deleted in some breast cancers. DBC-1 contains a nuclear localization signal, an N-terminal leucine zipper, an EF hand and a C-terminal coiled-coil region. DBC-1 is closely related to DIS but lacks the SAP domain. During death signaling mediated by TNFα, endogenous DBC-1 undergoes caspase-dependent processing to generate DBC-1 p120 and p66, both of which include the C-terminus of the protein. Both DBC-1 p120 and p66 relocate to the cytoplasm. Overexpression of the DBC-1 p120 form results in mitochondrial clustering and matrix condensation and increases the sensitivity of cells to TNFalpha-mediated apoptosis. In addition, DBC-1 directly interacts with unliganded ERalpha, stabilizing its expression and therefore collaborating to suppress apoptosis and promote hormone-independent cell growth. |
Synonyms | KIAA1967, DBC1, Deleted in breast cancer gene 1 protein, DBC.1, DBC-1, p30 DBC |
Reference Data |
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