JAB1 (COPS5) Rabbit Polyclonal Antibody

CAT#: AP20452PU-N

JAB1 (COPS5) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of JAB1 antibody (Cat.-No.: AP20452PU-N) in extracts from 293 cells.

• 

  Immunohistochemistry (IHC) analyzes of JAB1 antibody (Cat.-No.: AP20452PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of JAB1 protein.
  (region surrounding Lys191)
• Formulation: Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 38 kDa
• Gene Name: Homo sapiens COP9 signalosome subunit 5 (COPS5)
• Database Link:
  Entrez Gene 26754 MouseEntrez Gene 10987 Human
  UniProt ID Q92905
• Background: Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain.
• Synonyms: Signalosome subunit 5, SGN5, CSN5, JAB1

Reference Data

• Protein Families: Druggable Genome, Protease, Transcription Factors