MRTFA (MRTF-A) Rabbit Polyclonal Antibody

CAT#: AP20453PU-N

MRTFA (MRTF-A) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MRTF-A antibody (Cat.-No.: AP20453PU-N) in extracts from HUVEC cells.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to the N-terminal of Human MRTF-A.
• Specificity: This antibody detects endogenous levels of MRTF-A protein.
  (region surrounding His11)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
  Stabilizer: 50 % Glycerol
  Preservative: 0.02 % Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Predicted Protein Size: ~99 kDa
• Gene Name: Homo sapiens megakaryoblastic leukemia (translocation) 1 (MKL1), transcript variant 1
• Database Link:
  Entrez Gene 223701 MouseEntrez Gene 57591 Human
• Background: Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factor A (MRTF-A), also known as MKL1, interacts with SRF and stimulates its transcriptional activity.
• Synonyms: Mkl1, Bsac, Myocardin-related transcription factor A, MKL

Reference Data

• Protein Families: Transcription Factors