TSG101 Rabbit Polyclonal Antibody

CAT#: AP20455PU-N

TSG101 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Tsg 101 antibody (Cat.-No.: AP20455PU-N) in extracts from HEK293A cells.

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  Immunohistochemistry (IHC) analyzes of Tsg 101 antibody (Cat.-No.: AP20455PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
  Immunofluorescence: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Tsg 101 protein.
  (region surrounding Glu303)
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 45 kDa
• Gene Name: Homo sapiens tumor susceptibility 101 (TSG101)
• Database Link:
  Entrez Gene 22088 MouseEntrez Gene 292925 RatEntrez Gene 7251 Human
• Background: It is now well accepted that the transformation of a normal cell to one that is malignant can result from mutations in genes that encode proteins with key regulatory functions. Examples include the retinoblastoma gene product (Rb p110), p53, VHL and APC. Using a novel cloning strategy that allows the isolation of previously uncharacterized genes encoding selectable recessive phenotypes, an additional tumor suppressor gene has been identified. This gene, termed tsg 101 for tumor susceptibility gene 101, encodes a stathmin binding domain protein. When expression of this growth inhibitory gene is blocked in NIH/3T3 cells using antisense mRNA, the cells exhibit a transformed phenotype and are tumorigenic in SL6 mice.
• Synonyms: TSG10; VPS23

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Endocytosis