MAPK15 Rabbit Polyclonal Antibody

CAT#: AP20502PU-N

MAPK15 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of ERK8 antibody in extracts from HepG2 cells.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
  Immunofluorescence: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of ERK8 protein.
  (region surrounding Asp171)
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0,05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~60 kDa
• Gene Name: Homo sapiens mitogen-activated protein kinase 15 (MAPK15)
• Database Link:
  Entrez Gene 332110 MouseEntrez Gene 225689 Human
• Background: The ERKs are a subfamily of the MAPKs that have been implicated in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase whose activity is controlled by serum and the c-Src non-receptor tyrosine kinase. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRalpha by Hic-5 in a kinase-independent manner, suggesting a broader role for ERK8 in the regulation of nuclear receptors beyond estrogen receptor alpha. Erk8 is a novel effector of RET/PTC3 and, therefore, RET biological functions.
• Synonyms: Mitogen-activated protein kinase 15, ERK8

Reference Data

• Protein Families: Druggable Genome, Protein Kinase