RSK4 (RPS6KA6) Rabbit Polyclonal Antibody

CAT#: AP20537PU-N

RSK4 (RPS6KA6) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Rsk-4 antibody (Cat.-No.: AP20537PU-N) in extracts from K562 cells.

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  Immunohistochemistry (IHC) analyzes of Rsk-4 antibody (Cat.-No.: AP20537PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Rsk-4 protein.
  (region surrounding Gln688)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 84 kDa
• Gene Name: Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 (RPS6KA6)
• Database Link:
  Entrez Gene 27330 Human
• Background: The family of ribosomal S6 kinases (Rsks), designated Rsk-1 (MAPKAP kinase-1), Rsk-2 and Rsk-3, are intracellular serine/threonine kinases that are important signaling intermediates in response to a broad range of ligand activated receptor tyrosine kinases. A unique feature common to the members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. An additional Rsk protein, Rsk-4, shows a high level of homology to the three previously isolated members of the human Rsk family. Rsk-4 is most abundantly expressed in brain and kidney and plays a role in normal neuronal development. The 70 kDa family of ribosomal S6 kinases includes p70 S6 kinase and p70 S6 kinase beta, which are thought to have similar regulatory functions. MSK1 (also designated RLPK) is a novel Rskrelated protein, which, like the p90 Rsk family members, contains two non-identical complete kinase catalytic domains.
• Synonyms: RSK-4, Ribosomal S6 kinase 4, S6K-alpha-6, p90RSK6, p90-RSK 6, pp90RSK4

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Long-term potentiation, MAPK signaling pathway, mTOR signaling pathway, Neurotrophin signaling pathway, Oocyte meiosis, Progesterone-mediated oocyte maturation