FASTK Rabbit Polyclonal Antibody

CAT#: AP20588PU-N

FASTK rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of FAST antibody (Cat.-No.: AP20588PU-N) in extracts from pc12 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FAST protein.
  (region surrounding Arg410)
• Formulation: PBS, pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
  Preservative: 15 mM sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Predicted Protein Size: ~ 60 kDa
• Gene Name: Homo sapiens Fas activated serine/threonine kinase (FASTK), transcript variant 1
• Database Link:
  Entrez Gene 66587 MouseEntrez Gene 10922 Human
• Background: The Human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states. FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4. Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues. FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGβ and activin, indicating that these FAST proteins mediate TFGβ induced signal transduction.
• Synonyms: FASTK

Reference Data

• Protein Families: Druggable Genome, Protein Kinase