Peroxiredoxin 3 (PRDX3) Rabbit Polyclonal Antibody

CAT#: AP20593PU-N

Peroxiredoxin 3 (PRDX3) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of PRX III antibody (Cat.-No.: AP20593PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of PRX III antibody (Cat.-No.: AP20593PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of PRX III protein.
  (region surrounding Lys93)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 22 kDa
• Gene Name: Homo sapiens peroxiredoxin 3 (PRDX3), transcript variant 1
• Database Link:
  Entrez Gene 11757 MouseEntrez Gene 64371 RatEntrez Gene 10935 Human
  UniProt ID P30048
• Background: The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metalcatalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX I gene encodes a protein that is expressed in several tissues, including liver, kidney, testis, lung and nervous system. PRX II is expressed in testis, while PRX III shows expression in lung. PRX I, II and III are overexpressed in breast cancer and may be involved in its development or progression. Upregulated protein levels of PRX I and II in Alzheimer’s disease (AD) and Down syndrome (DS) indicate the involvement of PRX I and II in their pathogenesis.
• Synonyms: PRDX-3, Prx3, Prx-3, PRX-III, AOP-1, AOP1, HBC189

Reference Data

• Protein Families: Transcription Factors