S100A10 Rabbit Polyclonal Antibody

CAT#: AP20602PU-N

S100A10 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of S-100A10 antibody (Cat.-No.: AP20602PU-N) in extracts from COLO cells.

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  Immunohistochemistry (IHC) analyzes of S-100A10 antibody (Cat.-No.: AP20602PU-N) in paraffin-embedded human lung carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of S-100A10 protein.
  (region surrounding Val52)
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 11 kDa
• Gene Name: Homo sapiens S100 calcium binding protein A10 (S100A10)
• Database Link:
  Entrez Gene 20194 MouseEntrez Gene 81778 RatEntrez Gene 6281 Human
  UniProt ID P60903
• Background: The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.
• Synonyms: S100-A10, ANX2LG, CAL1L, CLP11, Calpactin-1 light chain

Reference Data

• Protein Families: Transmembrane