HIF3 alpha (HIF3A) (323-376) Rabbit Polyclonal Antibody

CAT#: AP20606PU-N

HIF3 alpha (HIF3A) (323-376) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of HIF3A Antibody (Cat.-No.- AP20606PU-N) in extracts from Rat brain cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 323-376 of Human HIF-3A
• Specificity: This antibody detects endogenous levels of HIF-3alpha protein.
  (region surrounding Glu354)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified IgG fraction (> 95% (by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Gene Name: Homo sapiens hypoxia inducible factor 3 alpha subunit (HIF3A), transcript variant 2
• Database Link:
  Entrez Gene 64344 Human
• Background: Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1α, HIF-1β (also designated Arnt 1), EPAS-1 (also designated HIF-2α) and HIF-3α, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
• Synonyms: HIF-3 alpha, Hypoxia-inducible factor 3 alpha, BHLHE17, MOP7, PASD7, Member of PAS protein 7, IPAS

Reference Data

• Protein Families: Druggable Genome, Transcription Factors