Neutrophil defensin 4 (DEFA4) Rabbit Polyclonal Antibody

CAT#: AP20620PU-N

Neutrophil defensin 4 (DEFA4) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of Defensin alpha 4 antibody at a 1/500 dilution. Lane 1: MCF-7 cell lysate. Lane 2: Mouse spleen tissue extract. Lane 3: Rat spleen tissue extract.

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  Immunohistochemistry analysis of Defensin alpha 4 antibody in paraffin-embedded human heart tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to the N-terminus of Human Defensin alpha 4.
• Specificity: This antibody detects endogenous levels of Defensin α4 protein.
  (region surrounding Asp27)
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Immunoaffinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 11 kDa
• Gene Name: Homo sapiens defensin alpha 4 (DEFA4)
• Database Link:
  Entrez Gene 1669 Human
• Background: Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteri,a fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. The cryptidin-4 gene is unique among the Paneth cell alpha defensins in that it is inactive in the duodenum, but expressed at maximal levels in the distal small bowel.
• Synonyms: Neutrophil defensin 4, HNP-4, HP-4, DEFA4, DEF4

Reference Data

• Protein Families: Secreted Protein