Cathepsin B (CTSB) Rabbit Polyclonal Antibody

CAT#: AP20651PU-N

Cathepsin B (CTSB) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Cathepsin B Antibody (Cat.-No.: AP20651PU-N) in extracts from COLO cells.

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  Immunohistochemistry analysis of Cathepsin B Antibody (Cat.-No.: AP20651PU-N) in Paraffin-Embedded Human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Cathepsin B protein.
  (region surrounding asn217)
• Formulation: Phosphate buffered saline (PBS), pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: One year from despatch.
• Predicted Protein Size: ~ 36 kDa
• Gene Name: Homo sapiens cathepsin B (CTSB), transcript variant 1
• Database Link:
  Entrez Gene 13030 MouseEntrez Gene 64529 RatEntrez Gene 1508 Human
  UniProt ID P07858
• Background: The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S and O. The aspartyl protease class is composed of cathepsins D and E. cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. cathepsin B is expressed in luminal epithelial cells, indicating that cathepsin B is a marker for secretory cell death.
• Synonyms: Cathepsin B1, APP secretase, APPS, CTSB, CPSB

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Antigen processing and presentation, Lysosome