KCNMA1 Rabbit Polyclonal Antibody

CAT#: AP20653PU-N

KCNMA1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MaxiKa antibody in extracts from HeLa cells.

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  Immunohistochemistry analyzes of MaxiKa antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 750-800 of Human MaxiKα
• Specificity: This antibody detects endogenous levels of MaxiKα protein.
  (region surrounding Gln770)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 137 kDa
• Gene Name: Homo sapiens potassium calcium-activated channel subfamily M alpha 1 (KCNMA1), transcript variant 1
• Database Link:
  Entrez Gene 16531 MouseEntrez Gene 83731 RatEntrez Gene 3778 Human
• Background: MaxiK channels are large conductance, voltage and calciumsensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the poreforming alpha subunit and the modulatory beta subunit. KCNMB2 is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents.
• Synonyms: Maxi K, BK, K VCA, BKCA channel, Slowpoke homolog, Slo-alpha, Slo1, hSlo

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Potassium, Transmembrane
• Protein Pathways: Vascular smooth muscle contraction