SLC22A6 Rabbit Polyclonal Antibody

CAT#: AP20669PU-N

SLC22A6 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of SLC22A6 / OAT1 Antibody at 1/500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: H9C2 whole cell lysate.

• 

  Immunohistochemistry analyzes of SLC22A6 / OAT1 Antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 271-320 of Human OAT1.
• Specificity: This antibody detects endogenous levels of OAT1 protein.
  (region surrounding Leu304).
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 15 mM Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 65 kDa
• Gene Name: Homo sapiens solute carrier family 22 member 6 (SLC22A6), transcript variant 1
• Database Link:
  Entrez Gene 18399 MouseEntrez Gene 29509 RatEntrez Gene 9356 Human
• Background: OAT1 (organic anion transporter 1), a 563 amino acid protein, and OAT3 (organic anion transporter 3), a 542 amino acid protein, are two members of the OAT family and are highly expressed in kidneys. Localized specifically to the basolateral membrane, OAT1 and OAT3 are involved in the elimination of toxic organic anions, such as benzylpenicillin and cimetidine, from proximal renal tubules. Via their ability to remove anions from renal tissues, OAT1 and OAT3 are able to regulate the amount of toxins within the kidneys. Additionally, OAT1 functions as an organic anion exchanger that couples the uptake of one organic anion molecule with the efflux of one endogenous dicarboxylic acid molecule, such as ketoglutarate.
• Synonyms: Organic anion transporter 1, ROAT, PAHT

Reference Data

• Protein Families: Transmembrane