FOXO4 Rabbit Polyclonal Antibody

CAT#: AP20684PU-N

FOXO4 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of FoxO4 antibody (Cat.-No.: AP20684PU-N) in extracts from COLO205 cells.

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  Immunohistochemistry (IHC) analyzes of FoxO4 antibody (Cat.-No.: AP20684PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FoxO4 protein.
  (region surrounding Pro191)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 55, 70 kDa
• Gene Name: Homo sapiens forkhead box O4 (FOXO4), transcript variant 1
• Database Link:
  Entrez Gene 54601 MouseEntrez Gene 4303 Human
• Background: FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulinresponse elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
• Synonyms: Forkhead box protein O4

Reference Data

• Protein Families: Transcription Factors