Stathmin 1 (STMN1) Rabbit Polyclonal Antibody

CAT#: AP20717PU-N

Stathmin 1 (STMN1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analyzes of Op18 antibody (Cat.-No.: AP20717PU-N) in extracts from HepG2 cells.

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  Immunohistochemistry analyzes of Op18 antibody (Cat.-No.: AP20717PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Op18 protein.
  (region surrounding Val31)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 19 kDa
• Gene Name: Homo sapiens stathmin 1 (STMN1), transcript variant 3
• Database Link:
  Entrez Gene 16765 MouseEntrez Gene 29332 RatEntrez Gene 3925 Human
  UniProt ID P16949
• Background: Op18 (for oncoprotein 18, also designated stathmin, prosolin or metablastin) is a conserved, tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of Op18 are observed, and it is expressed as two different isoforms. Op18 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phosphorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. Op18 is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.
• Synonyms: LAP18, OP18, Phosphoprotein p19, pp19, Leukemia-associated phosphoprotein p18, Oncoprotein 18, Op18, pp17, Prosolin, Metablastin, Protein Pr22

Reference Data

• Protein Pathways: MAPK signaling pathway