Aquaporin 3 (AQP3) Rabbit Polyclonal Antibody

CAT#: AP20765PU-N

Aquaporin 3 (AQP3) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemical analysis in paraffin-embedded human lung carcinoma tissue using Aquaporin-3 antibody (Cat.-No. AP20765PU-N).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on paraffin sections: 1/50 - 1/200.
  Western Blot: 1:500-1:1000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of AQP3 protein.
  (region surrounding Val214)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens aquaporin 3 (Gill blood group) (AQP3), transcript variant 1
• Database Link:
  Entrez Gene 11828 MouseEntrez Gene 65133 RatEntrez Gene 360 Human
  UniProt ID Q92482
• Background: Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. AQP2 is the only water channel that is activated by vasopressin to enhance water reabsorption in the kidney collecting duct. Aquaporins are involved in renal water absorption, generation of pulmonary secretions, lacrimation, and the secretion and reabsorption of cerebrospinal fluid and aqueous humor. AQP3 is expressed in the basolateral membrane by collecting duct cells in the kidney.
• Synonyms: AQP-3

Reference Data

• Protein Families: Druggable Genome, Transmembrane