Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

CAT#: AP20785PU-N

Angiotensin Converting Enzyme 2 (ACE2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of ACE2 antibody (Cat.-No.: AP20785PU-N) in extracts from HeLa cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of ACE2 protein.
  (region surrounding Lys465)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 92 kDa
• Gene Name: Homo sapiens angiotensin I converting enzyme 2 (ACE2)
• Database Link:
  Entrez Gene 70008 MouseEntrez Gene 59272 Human
• Background: Angiotensin-converting enzyme (ACE) is a carboxylterminal dipeptidyl exopeptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/ electrolyte homeostasis. ACE2 is the first known human homolog of angiotensin- converting enzyme (ACE). Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells.
• Synonyms: Angiotensin-converting enzyme 2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system