MET pTyr1234 Rabbit Polyclonal Antibody

CAT#: AP20840PU-N

MET pTyr1234 rabbit polyclonal antibody, Aff - Purified


USD 407.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution Western blot: 1/500-1/1000.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of Met protein only when phosphorylated at Tyr1234
Formulation PBS, pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~170 kDa
Gene Name Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant 2
Background The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met protooncogene product was identified as a transmembrane receptorlike protein with tyrosine kinase activity that is expressed in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibit transforming activity.Tyrosine phosphorylation of apparently normal Met protein has also been observed in certain human gastric carcinoma cell lines. Tyrosine phosphorylation enhances the receptor kinase activity, while serine phosphorylation of Met on residue 985 has an inhibitory effect. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.
Synonyms Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met
Reference Data
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.