H3FA (HIST1H3A) pSer10 Rabbit Polyclonal Antibody

CAT#: AP20893PU-N

H3FA (HIST1H3A) pSer10 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of p-Histone H3.1 antibody (Cat.-No.: AP20893PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of p-Histone H3.1 antibody (Cat.-No.: AP20893PU-N) in paraffin-embedded human malignant lymphoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of p-Histone H3.1 protein only when phosphorylated at Ser10.
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 17 kDa
• Gene Name: Homo sapiens histone cluster 1 H3 family member a (HIST1H3A)
• Database Link:
  Entrez Gene 360198 MouseEntrez Gene 679994 RatEntrez Gene 8350 Human
• Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.Covalent modifications of the canonical core histones, including acetylation, phosphorylation, methylation, and monoubiquitination are used to mark nucleosomes to create chromatin domains with a range of functions.
• Synonyms: H3/a, H3/b, H3/c, H3/d, H3/f, H3/h, H3/i, H3/j, H3/k, H3/l, HIST1H3A, H3FA, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Reference Data

• Protein Pathways: Systemic lupus erythematosus