JAK1 pTyr1022 Rabbit Polyclonal Antibody

CAT#: AP20955PU-N

JAK1 pTyr1022 rabbit polyclonal antibody, Aff - Purified


USD 370.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC
Recommended Dilution Western blot: 1:500 - 1:1000.
Immunohistochemistry on paraffin sections: 1:50 - 1:200.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of p-JAK1 (pTyr1022)protein.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2
State: Aff - Purified
State: Liquid Ig fraction
Concentration 1.0 mg/ml
Purification Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen, purity is > 95% (by SDS-PAGE)
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens Janus kinase 1 (JAK1), transcript variant 1
Background JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Synonyms Janus kinase 1, JAK-1, JAK1A, JAK1B
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.