EIF4EBP1 Rabbit Polyclonal Antibody

CAT#: AP20961PU-N

EIF4EBP1 rabbit polyclonal antibody, Aff - Purified


USD 370.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC
Recommended Dilution Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 40-90 of Human 4E-BP1.
Specificity This antibody detects endogenous levels of 4E-BP1 protein.
(region surrounding Pro71)
Formulation Phosphate buffered saline (PBS), pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% by SDS-PAGE)
Preservative: 0.05% sodium azide
Concentration 1.0 mg/ml
Purification affinity-Chromatography using epitope-specific immunogen
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 15 to 20 kDa
Gene Name Homo sapiens eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1)
Background The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
Synonyms PHAS-I, PHAS-1, PHAS1
Reference Data
Protein Pathways Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.