FOXO1 Rabbit Polyclonal Antibody

CAT#: AP20979PU-N

FOXO1 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of FKHR/FOXO1A antibody (Cat.-No.: AP20979PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of FKHR/FOXO1A antibody (Cat.-No.: AP20979PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of FKHR/FOXO1A protein.
  (region surrounding Ile325)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 70 to 82 kDa
• Gene Name: Homo sapiens forkhead box O1 (FOXO1)
• Database Link:
  Entrez Gene 56458 MouseEntrez Gene 84482 RatEntrez Gene 2308 Human
• Background: FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2); also known as alveolar rhabdomyosarcoma.
• Synonyms: Forkhead Box Protein O1, FOXO1, FKHR

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Insulin signaling pathway, Pathways in cancer, Prostate cancer