H3FA (HIST1H3A) Rabbit Polyclonal Antibody

CAT#: AP20984PU-N

H3FA (HIST1H3A) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analyzes of Histone H3.1 pAb in extracts from NIH/3T3 cells.

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  Immunohistochemistry (IHC) analyzes of Histone H3.1 pAb in paraffin-embedded human malignant lymphoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/500 - 1/1000.
  Immunohistochemistry: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Histone H3.1 pAb detects endogenous levels of Histone H3.1 protein.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1,0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Gene Name: Homo sapiens histone cluster 1 H3 family member a (HIST1H3A)
• Database Link:
  Entrez Gene 360198 MouseEntrez Gene 679994 RatEntrez Gene 8350 Human
• Background: In eukaryotes, DNA is wrapped around histone octamers to form the basic unit of chromatin structure. The octamer is composed of histones H2A, H2B, H3 and H4 and it associates with approximately 200 base pairs of DNA to form the nucleosome. The association of DNA with histones results in dense packing of chromatin, which restricts proteins involved in gene transcription from binding to DNA. Histone H1 is required for the condensation of nucleosome chains into higher order structures. Phosporylation of histone H1 is thought be involved in this process, although the exact nature of this role has yet to be elucidated. Evidence suggests that histone H1 is a part of a general repressor mechanism for stable repression of transcription, but it can also activate transcription of specific genes.
• Synonyms: H3/a, H3/b, H3/c, H3/d, H3/f, H3/h, H3/i, H3/j, H3/k, H3/l, HIST1H3A, H3FA, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Reference Data

• Protein Pathways: Systemic lupus erythematosus