CAMK2B Rabbit Polyclonal Antibody

CAT#: AP21111PU-N

CAMK2B rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CaMKIIbeta/gamma/delta antibody (Cat.-No.: AP21111PU-N) in extracts from rat brain cells.

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  Immunohistochemistry (IHC) analyzes of CaMKIIbeta/gamma/delta antibody (Cat.-No.: AP21111PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CaMKIIbeta/gamma/delta protein.
  (region surrounding Ser280)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 50, 65 kDa
• Gene Name: Homo sapiens calcium/calmodulin-dependent protein kinase II beta (CAMK2B), transcript variant 1
• Database Link:
  Entrez Gene 12323 MouseEntrez Gene 24245 RatEntrez Gene 816 Human
• Background: The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10–40-fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.
• Synonyms: CAM2, CAMKB, CaM-kinase II beta chain, CaM kinase II subunit beta, CaMK-II subunit beta, CAMKIIb

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway