NR2C2 Rabbit Polyclonal Antibody

CAT#: AP21115PU-N

NR2C2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Tak1 antibody (Cat.-No.: AP21115PU-N) in extracts from HepG2 cells.

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  Immunohistochemistry (IHC) analyzes of Tak1 antibody (Cat.: AP21115PU-N) in paraffin-embedded human breast carcinoma.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Tak1 protein.
  (region surrounding Asp181)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 70, 82 kDa
• Gene Name: Homo sapiens nuclear receptor subfamily 2 group C member 2 (NR2C2), transcript variant 1
• Database Link:
  Entrez Gene 22026 MouseEntrez Gene 50659 RatEntrez Gene 7182 Human
• Background: Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a 74 kDa protein with intrinsic kinase activity towards serine/threonine residues and that is widely expressed in many tissue types and cell lines. Raf-1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr-1 and Tak1. Ksr-1 (kinase suppressor of Ras) is a novel Raf-related protein kinase whose function is required for Ras signal transduction.
  Whether Ksr-1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFbeta-activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFbeta stimulation.
• Synonyms: TAK1, TR4

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors