MSK1 (RPS6KA5) Rabbit Polyclonal Antibody

CAT#: AP21118PU-N

MSK1 (RPS6KA5) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MSK1 antibody (Cat.-No.: AP21118PU-N) in extracts from mouse brain cells.

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  Immunohistochemistry (IHC) analyzes of MSK1 antibody (Cat.-No.: AP21118PU-N) in paraffin-embedded human colon carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of MSK1 protein.
  (region surrounding Asp205)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 90 kDa
• Gene Name: Homo sapiens ribosomal protein S6 kinase A5 (RPS6KA5), transcript variant 1
• Database Link:
  Entrez Gene 73086 MouseEntrez Gene 9252 Human
• Background: The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligandactivated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase beta shares high sequence homology with p70 S6 kinase,except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.
• Synonyms: Ribosomal protein S6 kinase alpha-5, RSKL

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors
• Protein Pathways: Bladder cancer, MAPK signaling pathway, Neurotrophin signaling pathway