Vitamin D Receptor (VDR) Rabbit Polyclonal Antibody

CAT#: AP21125PU-N

Vitamin D Receptor (VDR) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of VDR antibody (Cat.-No.: AP21125PU-N) in extracts from Jurkat cells.

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  Immunohistochemistry (IHC) analyzes of VDR antibody (Cat.-No.: AP21125PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of VDR protein.
  (region surrounding Lys45)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 48 kDa
• Gene Name: Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR), transcript variant 1
• Database Link:
  Entrez Gene 22337 MouseEntrez Gene 24873 RatEntrez Gene 7421 Human
• Background: The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.
• Synonyms: VDR, 1,25-dihydroxyvitamin D3 receptor

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors