Lamin A (LMNA) Rabbit Polyclonal Antibody

CAT#: AP21143PU-N

Lamin A (LMNA) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Lamin A antibody (Cat.-No.: AP21143PU-N) in extracts from HeLa cells.

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  Immunohistochemistry (IHC) analyzes of Lamin A antibody (Cat.-No.: AP21143PU-N) in paraffin-embedded human breast carcinoma tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Lamin A protein.
  (region surrounding Ser17)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 74 kDa
• Gene Name: Homo sapiens lamin A/C (LMNA), transcript variant 2
• Database Link:
  Entrez Gene 16905 MouseEntrez Gene 60374 RatEntrez Gene 4000 Human
• Background: A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed CED-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology.
• Synonyms: LMNA, LMN1, 70 kDa Lamin, NY-REN-32, NYREN32, Lamin-A/C, Lamin A, Lamin A + C, Nuclear Envelope Marker

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)