Neuroglycan C (CSPG5) Rabbit Polyclonal Antibody

CAT#: AP21148PU-N

Neuroglycan C (CSPG5) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Neuroglycan C antibody (Cat.-No.: AP21148PU-N) in extracts from THP1 and raw264.7 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Neuroglycan C protein.
  (region surrounding Trp248)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 60 kDa
• Gene Name: Homo sapiens chondroitin sulfate proteoglycan 5 (CSPG5), transcript variant 1
• Database Link:
  Entrez Gene 29873 MouseEntrez Gene 50568 RatEntrez Gene 10675 Human
  UniProt ID O95196
• Background: Neuroglycan C is a transmembrane chondroitin sulfate proteoglycan that is exclusively expressed in the central nervous system. NGC gene expression is developmentally regulated being altered by addiction to psychostimulants and by nerve lesion. Its core protein has a particular multidomain structure differing from those of other known proteoglycans, and this protein is modified post-translationally in various ways such as phosphorylation and glycosylation. Neuroglycan C is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate chains during the development of the cerebellum and retina. Evidence suggests that Neuroglycan C is involved in neuronal circuit formation in the central nervous system.
• Synonyms: Chondroitin sulfate proteoglycan 5,CSPG5, CALEB, NGC

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Transmembrane