Desmoglein 2 (DSG2) Rabbit Polyclonal Antibody

CAT#: AP21161PU-N

Desmoglein 2 (DSG2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Dsg2 antibody (Cat.-No.: AP21161PU-N) in extracts from HeLa cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Dsg2 protein.
  (region surrounding Val440)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 140 kDa
• Gene Name: Homo sapiens desmoglein 2 (DSG2)
• Database Link:
  Entrez Gene 1829 Human
  UniProt ID Q14126
• Background: Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.
• Synonyms: DSG2, CDHF5,HDGC

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC)