GGH Rabbit Polyclonal Antibody

CAT#: AP21177PU-N

GGH rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of GGH antibody (Cat.-No.: AP21177PU-N) in extracts from RAW264.7 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of GGH protein.
  (region surrounding Lys287)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Predicted Protein Size: ~ 36 kDa
• Gene Name: Homo sapiens gamma-glutamyl hydrolase (GGH)
• Database Link:
  Entrez Gene 8836 Human
• Background: GGH (gamma-glutamyl hydrolase), also known as GH or Gamma-Glu-X carboxypeptidase, is a 318 amino acid protein that is secreted into the extracellular space and is also localized to both the lysosome and the melanosome. Functioning as a hydrolase, GGH contains one gamma-glutamyl hydrolase domain through which it catalyzes the hydrolysis of polyglutamate sidechains from pteroylpolyglutamates, specifically hydrolyzing gamma-glutamyl bonds. Via its catalytic activity, GGH may play a role in the bioavailability and metabolic activity of pteroylpolyglutamates. Polymorphisms in the gene encoding GGH are associated with rheumatoid arthritis, inflammatory bowel disease and various cancers.
• Synonyms: Conjugase, GH

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Folate biosynthesis