IFI16 Rabbit Polyclonal Antibody

CAT#: AP21178PU-N

IFI16 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of IFI-16 antibody (Cat.-No.: AP21178PU-N) in extracts from HepG2 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of IFI-16 protein.
  (region surrounding asn772)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 88 kDa
• Gene Name: Homo sapiens interferon, gamma-inducible protein 16 (IFI16), transcript variant 2
• Database Link:
  Entrez Gene 3428 Human
• Background: Interferon-gamma inducible protein 16 (IFI16) belongs to the HIN-200 family of transcriptional regulator linked to cell cycle regulation and differentiation by modulating the activities of multiple transcriptional factors, such as p53 and Rb. The HIN-200 (hematopoeitic interferon-inducible nuclear antigens with 200 amino acid repeat) family members contain a DNA binding domain, a transcriptional regulatory domain, DAPIN/PAAD domain associated with interferon response and a binding domain for BRCA1. IFI16 may have a role in the regulation of hematopoeitic cell differentiation and also be involved in DNA repair since it becomes a component of the DNA repair multi-protein BASC complex after UV-induced DNA damage. IFI16 is strongly induced by gamma interferon in vivo.
• Synonyms: IFI-16

Reference Data

• Protein Families: Transcription Factors