Microsomal Glutathione S transferase 1 (MGST1) Rabbit Polyclonal Antibody

CAT#: AP21192PU-N

Microsomal Glutathione S transferase 1 (MGST1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of MGST1 antibody (Cat.-No.: AP21192PU-N) in extracts from HeLa cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of MGST1 protein.
  (region surrounding Arg74)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 18 kDa
• Gene Name: Homo sapiens microsomal glutathione S-transferase 1 (MGST1), transcript variant 2
• Database Link:
  Entrez Gene 4257 Human
  UniProt ID P10620
• Background: Microsomal glutathione transferase 1 (MGST1) is an abundant protein that catalyzes the conjugation of electrophilic compounds with glutathione, as well as the reduction of lipid hydroperoxides. The level of MGST1 mRNA in rat are highest in liver, while the levels of expression vary in non-hepatic tissues. In addition, the subcellular localization patterns of MGST1 are highly tissue specific. In hepatocytes and bile ducts, MGST1 is localized to the cytoplasm. MGST1 is localized to the nucleus in choroid plexus and primary spermatocytes and displays a granular cytoplasmic staining pattern in the adrenal medulla). Also, focal staining of MGST1 is observed in the distal tubules and collecting ducts of the liver.
• Synonyms: Microsomal GST-1, GST12, MGST

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Drug metabolism - cytochrome P450, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450