NCR3 Rabbit Polyclonal Antibody

CAT#: AP21200PU-N

NCR3 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of NKp30 antibody (Cat.-No.: AP21200PU-N) in extracts from A549 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This detects endogenous levels of NKp30 protein.
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE)
• Predicted Protein Size: ~ 30 kDa
• Gene Name: Homo sapiens natural cytotoxicity triggering receptor 3 (NCR3), transcript variant 1
• Database Link:
  Entrez Gene 294251 RatEntrez Gene 259197 Human
• Background: The p30-15 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on IL-2 activated NK cells and NK cell lines as well as some in vitro activated γ/δ T cells. NKp30 enhances NK cell triggering and cytolysis of tumor targets and other target cells deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The p30-15 antibody against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution.
• Synonyms: NKp30, NCR3, 1C7, LY117

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS
• Protein Pathways: Natural killer cell mediated cytotoxicity