SNAP23 Goat Polyclonal Antibody

CAT#: AP21296PU-N

SNAP23 goat polyclonal antibody, Aff - Purified


USD 375.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution Peptide ELISA: Limit Dilution: 1/8000.
Western blot: 0.1-0.3 µg/ml. This antibody detects a band of ~26kDa Human Placenta lysates. 
Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
Reactivities Bovine, Human, Mouse, Rat
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_003816.2 and NP_570710.1.
Specificity This antibody is expected to recognize both reported isoforms (NP_003816.2 and NP_570710.1).
Formulation Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Gene Name Homo sapiens synaptosome associated protein 23kDa (SNAP23), transcript variant 1
Background Synaptosomal-associated proteins (SNAPs) are cytosolic proteins that play a key role in in the process of membrane fusion in intracellular vesicle trafficking. In eukaryotic cells, the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex is critical to membrane docking and fusion and is believed to impart some degree of specificity between vesicle SNARE (v-SNARE) and target organelle SNARE (t-SNARE). In neurons and neuroendocrine cells, the SNARE complex consists of the integral membrane proteins VAMP (vesicle-associated membrane protein), syntaxin and SNAP-25. In non-neuronal tissue, a SNAP-25 homolog, SNAP-23, functionally replaces SNAP-25 in the SNARE complex. Studies show that VAMP, syntaxin and SNAP-23 are required for SNARE function and that this complex exists as a heterotrimer of the three proteins. In insulin signalling pathways, studies suggest that the translocation of GLUT4 in adipocytes requires that functional SNAP-23 be present in SNARE complexes.
Synonyms SNAP-23
Note Calculated Molecular Weight: 23.4kDa (NP_003816.2
Reference Data
Protein Families Druggable Genome
Protein Pathways SNARE interactions in vesicular transport

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