SynCAM (CADM1) Goat Polyclonal Antibody

CAT#: AP21519PU-N

SynCAM (CADM1) goat polyclonal antibody, Aff - Purified

Product Images

CADM1 Antibody staining of Mouse Heart lysate at 0.1 ug/ml (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: Peptide ELISA: 1/16000 (Detection limit).
  Western blot: 0.1-0.3 µg/ml. Approx 42kDa band observed in Mouse Heart lysates (Calculated MW of 45.8kDa according to Mouse NP_001020771.1).
• Reactivities: Bovine, Canine, Human, Mouse, Rat
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_055148.3; NP_001091987.1.
• Specificity: This antibody is expected to recognize both reported isoforms (NP_055148.3 and NP_001091987.1).
• Formulation: Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
• Gene Name: Homo sapiens cell adhesion molecule 1 (CADM1), transcript variant 2
• Database Link:
  Entrez Gene 54725 MouseEntrez Gene 363058 RatEntrez Gene 23705 Human
• Background: Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with binding with other cells or with the extracellular matrix. SynCAM belongs to immunoglobulin superfamily 4 and is involved in cell-cell adhesion. Loss of SynCAM is common in a number of cancers including lung, breast, prostate and meningioma. This loss of SynCAM in advanced stage cancers suggests a role in tumor invasion and/or metastasis. Also recent studies have shown that SynCAM suppresses induction of EMT (epithelial mesenchymal transition) via regulation of Rho GTPases.
• Synonyms: IGSF4, IGSF4A, NECL2, TSLC1, NECL-2, SgIgSF, TSLC-1

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)