Aromatase (CYP19A1) (475-486) Goat Polyclonal Antibody

CAT#: AP22508PU-N

Aromatase (CYP19A1) (475-486) goat polyclonal antibody, Aff - Purified

Product Images

Antibody (0.1 ug/ml) staining of Human Placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

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  Human Placenta (formalin-fixed, paraffin-embedded) stained with CYP19A1 antibody at 4 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 4 µg/ml.
  Western Blot: 0.1 - 0.3 µg/ml.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from internal region of human CYP19A1
• Specificity: This antibody detects Aromatase at aa 475-486.
  It is expected to recognise both reported isoforms (NP_000094.2 and NP_112503.1), which are identical.
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cytochrome P450 family 19 subfamily A member 1 (CYP19A1), transcript variant 1
• Database Link:
  Entrez Gene 1588 Human
• Background: Aromatase, also known as estrogen synthetase, is a P450 enzyme that catalyzes the formation of aromatic C18 estrogens from C19 androgens. Aromatase is present in many tissues including skin, muscle, brain, adipose, and placenta where it may contribute to sex-specific differences in cellular metabolism.
• Synonyms: Cytochrome P450 19A1, CYPXIX, Estrogen synthetase, P450AROM, CYP19A1, ARO1, CYAR, CYP19

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Androgen and estrogen metabolism, Metabolic pathways